Flonase nasal spray application

Mechanism of action of Fluticasone

Fluticasone is a synthetic trifluorinated corticosteroid produced in the form of nasal spray, 50 mcg for topical application. The medicine is applied directly to the nasal mucosa by atomizing spray pump. The anti-inflammatory effects of the medicine are associated with progesterone-like activity of Fluticasone.

The exact mode of Fluticasone action is not known, it is supposed to be linked to effects which corticosteroids produce on cells and mediatros (histamine and others) which are responsible for inflammation in the body.

Clinical trials of Flonase nasal spray have demonstrated beneficial results of the medicine in reduction of nasal mucosal eosinophils and basophils.

Flonase does not show the immediate effect on allergic symptoms of the disease. Usually the result is seen within 12 hours of more.

The effect stays for several days when the treatment is stopped


Flonase (fluticasone propionate) nasal spray, 50 mcg is indicated for intranasal usage only. Before using this spray it should be shaken. The amount applied should not exceed the recommended dose.

Prior to the first application, the bottle with spray should be shaken well, and then the content should be diffused several times. After that the spray is ready for use.

Flonase should not be used longer than recommended by a doctor. If you symptoms do not improve, ask your doctor. Try to use the medicine with accordance to the doctor’s advice. Do not use it more frequently than recommended. Topical application of the medicine gives the needed effect in the place of use and does not affect the whole body or body systems anyhow.

Usually doctors recommend 1-2 sprays of Flonase each day of the treatment. The symptoms of your condition can improve only two or three days after the treatment is started.

The bottle with a medicine should be disposed when it has been applied 120 times (120 sprays). It is necessary to prime the pump before first use. Each actuation delivers 50 mcg of fluticasone in 100 mg of formulation through the nasal adapter. Each 16-g bottle of Flonase Nasal Spray provides 120 metered sprays.

The medicine should be stored in a dark cold place out of reach of children and pets. The spray should be applied only by a person for whom it is prescribed. Don’t give the medicine to the others even if they have the same symptoms as you.

Before using Flonase

Before using this medicine one should make sure that he/she does not have allergic reactions to the components. In case a patient has previously experienced allergic reactions to Flonase, the medicine should not be applied.
If a patient is taking ritonavir (Norvir, Kaletra) the use of Flonase is contraindicated.
Before using this drug for the first time, consult your doctor. Discuss with your doctor the possibility of Flonase use if you have any of the following:
•    glaucoma or cataracts;
•    kidney or liver disease;
•    herpes simplex virus in the eye;
•    pregnancy;
•    tuberculosis;
•    any infectious disease caused by bacteria;
•    sores or ulcers inside the nose;
•    a history of injury of the nose or surgery on the nose.
Diabetics should discuss the use of Flonase with a doctor because the medicine may increase blood sugar level.

Flonase Important Information

Flonase use should be discussed with a GP. If you have allergies to any component of the medicine or taking ritonavir (Norvir, Kaletra) do not use Flonase.
Patients with glaucoma or cataracts, liver disease, diabetes, herpes simplex virus of your eyes, tuberculosis, other infectious diseases should not use this medicine.
If you have recently had injury of or surgery on your nose ask your doctor if you can safely use this medicine.
Flonase may show its action only a few days after starting the treatment. The symptoms may start to improve on the 2nd or 3rd day of the therapy.
Children younger than 2 years old should not be treated with this medicine.

Flonase with other drugs


Tell your specialist of health or provider about all other drugs or treatment you use, especially:

• imatinib (Gleevec);

• conivaptan (Vaprisol);

• HIV/AIDS drugs;

• antifungal medication: ketoconazole (Nizoral), itraconazole (Sporanox), voriconazole (Vfend), miconazole (Oravig);

• isoniazid;

• an antibiotic: telithromycin (Ketek), erythromycin (E.E.S., Ery-Tab, EryPed,  Pediazole, Erythrocin), clarithromycin (Biaxin),

• nefazodone;

• blood pressure/heart drugs : quinidine (Quin-G), nicardipine (Cardene).


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Serious and less serious side effects of Flonase

Serious side effects may include the next symptoms:

  •  any wound that will not heal; or
  •  ongoing or severe  nosebleeds;
  •  crusting around your nostrils, runny nose, noisy breathing;
  •  white patches in your  throat or mouth, sores, redness;
  •  weakness,fever,vomiting,  nausea, flu symptoms;
  •  seeing halos around lights, blurred vision, chills, eye pain.

Less serious Flonase side effects may include the next symptoms:

  • white patches or sores around or  inside  your nose.
  • back pain, headache;
  • minor nosebleed;
  • loss of interest in sex, menstrual problems;
  • cough,  sinus pain, sore throat.

What is allergic conjunctivitis?

Conjunctivitis is one of the most common eye diseases occurring in children and adults. It is an inflammation of the conjunctiva, whose role is to maintain the natural moisture of the eye.

Conjunctivitis can be caused by irritating substances (shampoos, shower, dust, smoke, chlorinated pool water, light which is too bright and so on). Conjunctivitis is sometimes associated with infectious diseases.

Conjunctivitis is often accompanied by rhinitis causing runny nose, sneezing and tear-shedding. The contact with substances to which the patient is sensibile (allergen) results in allergic conjunctivitis.

What is allergic rhinitis?

Rhinitis is manifested by the inflammation of the nasal passages. This inflammation is triggered by allergens such as dust, pollen and smoke cigarettes. Allergic rhinitis can provoke a lot of annoying symptoms like sneezing, itching, nasal congestion, runny nose, post-nasal drip, etc.

Allergic rhinitis often appears with vasomotor rhinitis in which the nose is extremely sensitive to irritants such as cigarette smoke and other pollutants as well as changes in temperature and humidity, certain foods, drugs and emotional stress. Other allergic diseases such as asthma and atopic dermatitis also increase the risk of allergic rhinitis.

For many people, rhinitis is a trouble for term of life. Fortuitously, the symptoms of rhinitis can usually be controlled with a combination of medications, immunotherapy and environment changes.

Flonase in combination with Azelastine is effective against allergic rhinitis

According to the results of a study published in March 2012 by the “Journal of Allergy and Clinical Immunology” the combination therapy with azelastine and fluticasone is more effective in the treatment of seasonal allergic rhinitis compared to monotherapy with these drugs.

Dr. Warner Carr and his colleagues have realized a study of three multicenter, randomized, controlled, double-blind trial of 3398 patients aged ≥ 12 years with allergic rhinitis. Each study underwent during 14 days in different seasons of allergies.

Symptoms of allergic rhinitis were evaluated using TNSS scale (Total Nasal Symptom Score) throughout the experimental period.

A meta-analysis showed that the reduction of allergic rhinitis symptoms was more pronounced in patients treated with the combination of both drugs. In comparison with the base period to the end of the study, the mean scores of the TNSS have decreased by 5.7 points in the combined treatment group, by 5.1 points in the group fluticason, by 4.4 points in the azelastine group and by 3.0 points in the placebo group. The advantages of combination therapy were observed from the first day of the study, even in patients with the most severe form of the disease.

The results of this study clearly demonstrate greater efficacy of combined treatment with fluticasone and azelastine compared to monotherapy with these drugs in patients with moderate or severe allergic rhinitis.

Flonase: dosage and administration

For adults: the usual dosage is 2 sprays in each nostril once a day.

For children aged 4 and older: 1 spray in each nostril once a day.

Flonase take effects within 12 hours of the first dose, but it takes several days of regular use to reach its greatest effect. Best results you may obtain by using the spray on a regular basis.

If you forgot to take a dose, just take your next dose when it is due. Do not double the dose.

The maximum total daily dosage should not exceed 2 sprays in each nostril.

It is not recommended for children under 4 years old, because safety for them have not been adequately established.

FLONASE: ​​fighting with rhinitis


Flonase Nasal Spray is used for treatment of  the nasal symptoms of seasonal  and perennial allergic and nonallergic rhinitis in adults and children 4 years of age and older.
Flonase include fluticasone propionate, which is a synthetic corticosteroid. Corticosteroid is natural substance found in the body that help fight inflammation.  Flonase Nasal Spray helps to reduce the symptoms of allergic reactions such as stuffiness, itching and sneezing.

Side effects

Severe or ongoing nosebleeds, redness, sores, or white patches in your mouth or throat, fever, chills, weakness, nausea, vomiting, blurred vision, eye pain, noisy breathing, runny nose, or crusting around your nostrils.


Flonase Nasal Spray is contraindicated in patients with a hypersensitivity to any of its ingredients and if you are also taking ritonavir.