Mechanism of action of Fluticasone
Fluticasone is a synthetic trifluorinated corticosteroid produced in the form of nasal spray, 50 mcg for topical application. The medicine is applied directly to the nasal mucosa by atomizing spray pump. The anti-inflammatory effects of the medicine are associated with progesterone-like activity of Fluticasone.
The exact mode of Fluticasone action is not known, it is supposed to be linked to effects which corticosteroids produce on cells and mediatros (histamine and others) which are responsible for inflammation in the body.
Clinical trials of Flonase nasal spray have demonstrated beneficial results of the medicine in reduction of nasal mucosal eosinophils and basophils.
Flonase does not show the immediate effect on allergic symptoms of the disease. Usually the result is seen within 12 hours of more.
The effect stays for several days when the treatment is stopped
Flonase (fluticasone propionate) nasal spray, 50 mcg is indicated for intranasal usage only. Before using this spray it should be shaken. The amount applied should not exceed the recommended dose.
Prior to the first application, the bottle with spray should be shaken well, and then the content should be diffused several times. After that the spray is ready for use.
Flonase should not be used longer than recommended by a doctor. If you symptoms do not improve, ask your doctor. Try to use the medicine with accordance to the doctor’s advice. Do not use it more frequently than recommended. Topical application of the medicine gives the needed effect in the place of use and does not affect the whole body or body systems anyhow.
Usually doctors recommend 1-2 sprays of Flonase each day of the treatment. The symptoms of your condition can improve only two or three days after the treatment is started.
The bottle with a medicine should be disposed when it has been applied 120 times (120 sprays). It is necessary to prime the pump before first use. Each actuation delivers 50 mcg of fluticasone in 100 mg of formulation through the nasal adapter. Each 16-g bottle of Flonase Nasal Spray provides 120 metered sprays.
The medicine should be stored in a dark cold place out of reach of children and pets. The spray should be applied only by a person for whom it is prescribed. Don’t give the medicine to the others even if they have the same symptoms as you.